{"id":15116,"date":"2026-07-21T08:43:18","date_gmt":"2026-07-21T08:43:18","guid":{"rendered":"https:\/\/www.totarolchina.com\/?p=15116"},"modified":"2026-07-21T08:43:19","modified_gmt":"2026-07-21T08:43:19","slug":"retinol-and-ferulic-acid-overcoming-formulation-instability-and-skin-irritation","status":"publish","type":"post","link":"https:\/\/www.totarolchina.com\/ja\/retinol-and-ferulic-acid-overcoming-formulation-instability-and-skin-irritation\/","title":{"rendered":"\u30ec\u30c1\u30ce\u30fc\u30eb\u3068\u30d5\u30a7\u30eb\u30e9\u9178\uff1a\u88fd\u5264\u306e\u4e0d\u5b89\u5b9a\u6027\u3068\u76ae\u819a\u523a\u6fc0\u306e\u514b\u670d"},"content":{"rendered":"
\n

\u914d\u5408\u3092\u3084\u3081\u308b \u9ad8\u7d14\u5ea6\u7d50\u6676\u30ec\u30c1\u30ce\u30fc\u30eb<\/span>\u7d14\u7c8b\u306a\u30ec\u30c1\u30ce\u30fc\u30eb\uff08\u7d14\u5ea698%\uff09\u306f\u975e\u5e38\u306b\u4e0d\u5b89\u5b9a\u3067\u3059\u3002\u9178\u7d20\u3001\u5149\u3001\u71b1\u306b\u3055\u3089\u3055\u308c\u308b\u3068\u6025\u901f\u306b\u5206\u89e3\u3057\u307e\u3059\u3002\u5de5\u5834\u3067\u7d14\u7c8b\u306a\u30ec\u30c1\u30ce\u30fc\u30eb\u7c89\u672b\u3092\u53d6\u308a\u6271\u3046\u3053\u3068\u306f\u3001\u4f5c\u696d\u8005\u306b\u3068\u3063\u3066\u5b89\u5168\u4e0a\u306e\u5371\u967a\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u5c02\u9580\u30e1\u30fc\u30ab\u30fc\u306f\u3001\u307b\u307c\u72ec\u5360\u7684\u306b\u5b89\u5b9a\u5316\u3055\u308c\u305f\u5f62\u614b\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001BHT\u3092\u6dfb\u52a0\u3057\u305f\u5927\u8c46\u6cb9\u306b\u6eb6\u89e3\u3057\u305f\u30ec\u30c1\u30ce\u30fc\u30eb\u3001\u307e\u305f\u306f \u30ea\u30dd\u30bd\u30fc\u30e0\u5c01\u5165\u30ec\u30c1\u30ce\u30fc\u30eb<\/span>.<\/p>\n\n

\u914d\u5408\u62c5\u5f53\u8005\u306f\u3001\u30ec\u30c1\u30ce\u30a4\u30c9\u306b\u95a2\u3057\u30662\u3064\u306e\u5927\u304d\u306a\u554f\u984c\u306b\u76f4\u9762\u3057\u3066\u3044\u307e\u3059\u3002\u30dc\u30c8\u30eb\u5185\u3067\u306e\u5316\u5b66\u7684\u5206\u89e3\u3068\u3001\u808c\u3078\u306e\u751f\u7269\u5b66\u7684\u523a\u6fc0\u3067\u3059\u3002\u6700\u521d\u306e\u554f\u984c\u306f\u30ea\u30dd\u30bd\u30fc\u30e0\u3067\u89e3\u6c7a\u3067\u304d\u307e\u3059\u30022\u756a\u76ee\u306e\u554f\u984c\u306f\u30d5\u30a7\u30eb\u30e9\u9178\u3067\u89e3\u6c7a\u3067\u304d\u307e\u3059\u3002<\/p>\n\n

\u30ec\u30c1\u30ce\u30fc\u30eb\u306f\u30ec\u30c1\u30ce\u30a4\u30c9\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u7d30\u80de\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u52a0\u901f\u3057\u307e\u3059\u304c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u8a98\u767a\u3057\u307e\u3059\u3002\u808c\u306f\u8d64\u304f\u306a\u308a\u3001\u4e7e\u71e5\u3057\u3001\u5265\u304c\u308c\u307e\u3059\u3002\u6d88\u8cbb\u8005\u306f\u3053\u308c\u3092\u5acc\u3044\u307e\u3059\u3002\u30d5\u30a7\u30eb\u30e9\u9178\u306f\u751f\u7269\u5b66\u7684\u30d0\u30c3\u30d5\u30a1\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u690d\u7269\u7531\u6765\u306e\u5f37\u529b\u306a\u6297\u9178\u5316\u7269\u8cea\u3067\u3059\u3002\u76ae\u819a\u306e\u708e\u75c7\u4e2d\u306b\u751f\u6210\u3055\u308c\u308b\u6d3b\u6027\u9178\u7d20\u7a2e\u3092\u4e2d\u548c\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u30ec\u30c1\u30ce\u30fc\u30eb\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u4fc3\u9032\u52b9\u679c\u3092\u3001\u91cd\u5ea6\u306e\u8868\u76ae\u30d0\u30ea\u30a2\u7834\u58ca\u306a\u3057\u306b\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n

\u73fe\u5b9f\u7684\u306a\u539f\u6599\u4ed5\u69d8<\/h2>\n

\u73fe\u5b9f\u7684\u306a\u539f\u6599\u4ed5\u69d8\u3092\u898b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u7406\u8ad6\u7684\u306a\u7d14\u5ea6\u3060\u3051\u3067\u539f\u6599\u3092\u8abf\u9054\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u914d\u5408\u306e\u5b9f\u73fe\u53ef\u80fd\u6027\u306b\u57fa\u3065\u3044\u3066\u8abf\u9054\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n \n \n \n \n \n \n \n \n \n
\u4ed5\u69d8\u30d1\u30e9\u30e1\u30fc\u30bf<\/th>\n \u30ec\u30c1\u30ce\u30fc\u30eb\uff0810% \u30ea\u30dd\u30bd\u30fc\u30e0\u61f8\u6fc1\u6db2\uff09<\/th>\n \u30d5\u30a7\u30eb\u30e9\u9178\uff0898% \u5929\u7136\u62bd\u51fa\u7269\uff09<\/th>\n <\/tr>\n <\/thead>\n
\u5916\u89b3<\/td>\n \u9ec4\u8272\u4e0d\u900f\u660e\u7c98\u7a20\u6db2<\/td>\n \u767d\u8272\uff5e\u30aa\u30d5\u30db\u30ef\u30a4\u30c8\u306e\u7d50\u6676\u6027\u7c89\u672b<\/td>\n <\/tr>\n
\u6709\u52b9\u6210\u5206\u30a2\u30c3\u30bb\u30a4<\/td>\n 0% \u2013 11.0% (HPLC)<\/td>\n NLT 98.0% (HPLC)<\/td>\n <\/tr>\n
\u6eb6\u89e3\u6027<\/td>\n \u6c34\u5206\u6563\u6027<\/td>\n \u6c34\u306b\u96e3\u6eb6\u3002\u30d7\u30ed\u30d1\u30f3\u30b8\u30aa\u30fc\u30eb\u3001DMI\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u306b\u53ef\u6eb6\u3002<\/td>\n <\/tr>\n
\u6700\u9069pH\u7bc4\u56f2<\/td>\n 5.5 – 6.5<\/td>\n 3.0 – 5.0<\/td>\n <\/tr>\n
\u4fdd\u7ba1\u6e29\u5ea6<\/td>\n 2\u00b0C \u2013 8\u00b0C (\u51b7\u8535)<\/td>\n \u5ba4\u6e29\u3001\u906e\u5149<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n\n

\u914d\u5408\u306e\u8ab2\u984c\uff1a\u30bf\u30fc\u30b2\u30c3\u30c8\u6eb6\u5a92\u30b7\u30b9\u30c6\u30e0<\/h2>\n

\u672c\u5f53\u306e\u8ab2\u984c\u306f\u3001\u305d\u308c\u3089\u3092\u6df7\u5408\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u30d5\u30a7\u30eb\u30e9\u9178\u3092\u6c34\u76f8\u306b\u305d\u306e\u307e\u307e\u52a0\u3048\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u975e\u5e38\u306b\u6271\u3044\u306b\u304f\u3044\u3067\u3059\u3002\u6c34\u309280\u00b0C\u306b\u52a0\u71b1\u3059\u308b\u3068\u3001\u30d5\u30a7\u30eb\u30e9\u9178\u306f\u6eb6\u89e3\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a8\u30de\u30eb\u30b7\u30e7\u30f3\u304c\u51b7\u3048\u308b\u3068\u3059\u3050\u306b\u518d\u7d50\u6676\u3057\u307e\u3059\u3002\u7d50\u679c\u3068\u3057\u3066\u30b6\u30e9\u30b6\u30e9\u3057\u305f\u7f8e\u5bb9\u6db2\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n\n

\u30bf\u30fc\u30b2\u30c3\u30c8\u6eb6\u5a92\u30b7\u30b9\u30c6\u30e0\u304c\u5fc5\u8981\u3067\u3059\u3002 \u30d7\u30ed\u30d1\u30f3\u30b8\u30aa\u30fc\u30eb<\/span> \u304a\u3088\u3073 \u30b8\u30e1\u30c1\u30eb\u30a4\u30bd\u30bd\u30eb\u30d3\u30c9\uff08DMI\uff09<\/span> \u306f\u4f8b\u5916\u7684\u306b\u3046\u307e\u304f\u6a5f\u80fd\u3057\u307e\u3059\u3002<\/p>\n\n

\n

\u5b9f\u8df5\u7684\u306a\u30d5\u30ec\u30fc\u30e0\u30ef\u30fc\u30af\uff1a0.3% \u30ec\u30c1\u30ce\u30fc\u30eb + 0.5% \u30d5\u30a7\u30eb\u30e9\u9178\u7f8e\u5bb9\u6db2<\/h3>\n
    \n
  1. \u6eb6\u5a92\u76f8\uff1a<\/strong> \u30d5\u30a7\u30eb\u30e9\u9178 0.5% \u3092\u30d7\u30ed\u30d1\u30f3\u30b8\u30aa\u30fc\u30eb 5.0% \u304a\u3088\u3073 DMI 3.0% \u3068\u6df7\u5408\u3057\u307e\u3059\u3002\u5b8c\u5168\u306b\u900f\u660e\u306b\u306a\u308b\u307e\u3067\u7a4f\u3084\u304b\u306b\u52a0\u71b1\u3057\u307e\u3059\u3002\u3053\u308c\u3092\u4e3b\u6c34\u76f8\u306b\u52a0\u3048\u307e\u3059\u3002<\/li>\n
  2. \u4e73\u5316\uff1a<\/strong> \u6a19\u6e96\u7684\u306aO\/W\u30a8\u30de\u30eb\u30b7\u30e7\u30f3\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/li>\n
  3. \u51b7\u5374\u76f8\uff1a<\/strong> \u30d0\u30c3\u30c1\u6e29\u5ea6\u304c40\u00b0C\u3092\u4e0b\u56de\u308b\u307e\u3067\u5f85\u3061\u307e\u3059\u3002 \u71b1\u3044\u30d0\u30c3\u30c1\u306b\u30ec\u30c1\u30ce\u30fc\u30eb\u3092\u7d76\u5bfe\u306b\u5165\u308c\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/span><\/li>\n
  4. \u6709\u52b9\u6210\u5206\u306e\u6dfb\u52a0\uff1a<\/strong> \u6700\u7d42\u7684\u306a\u6709\u52b9\u6210\u5206\u6fc3\u5ea60.3%\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u3001\u30ea\u30dd\u30bd\u30fc\u30e0\u30ec\u30c1\u30ce\u30fc\u30eb 3.0% \u3092\u52a0\u3048\u307e\u3059\u3002<\/li>\n <\/ol>\n <\/div>\n\n

    pH\u306e\u7af6\u5408\u7ba1\u7406<\/h2>\n

    \u6b21\u306b\u3001pH\u306e\u7af6\u5408\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u30d5\u30a7\u30eb\u30e9\u9178\u306f\u81ea\u7136\u306b\u51e6\u65b9\u306epH\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002pH\u304c4.5\u3092\u4e0b\u56de\u308b\u3068\u3001\u30ea\u30dd\u30bd\u30fc\u30e0\u30ec\u30c1\u30ce\u30fc\u30eb\u306e\u69cb\u9020\u304c\u5d29\u58ca\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30ec\u30c1\u30ce\u30fc\u30eb\u304c\u6f0f\u308c\u51fa\u3057\u3001\u5206\u89e3\u3057\u307e\u3059\u3002\u6700\u7d42\u7684\u306a\u30a8\u30de\u30eb\u30b7\u30e7\u30f3\u3092\u30d0\u30c3\u30d5\u30a1\u30fc\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6c34\u9178\u5316\u30ca\u30c8\u30ea\u30a6\u30e0\u307e\u305f\u306fL-\u30a2\u30eb\u30ae\u30cb\u30f3\u3092\u4f7f\u7528\u3057\u3066\u3001\u6700\u7d42\u7684\u306apH\u3092\u6b63\u78ba\u306b\u8abf\u6574\u3057\u307e\u3059\u3002 5\uff5e6.0<\/span>\u3002\u3053\u308c\u306f\u4e21\u65b9\u306e\u5206\u5b50\u304c\u751f\u5b58\u3067\u304d\u308b\u30b9\u30a4\u30fc\u30c8\u30b9\u30dd\u30c3\u30c8\u3067\u3059\u3002<\/p>\n\n

    \u5e02\u5834\u9069\u5408\u6027\u3068\u76f8\u4e57\u52b9\u679c<\/h2>\n

    \u5e02\u5834\u9069\u5408\u6027\u306b\u3064\u3044\u3066\u8a71\u3057\u307e\u3057\u3087\u3046\u3002\u6b27\u5dde\u9023\u5408\u306eSCCS\u306f\u898f\u5247\u3092\u53b3\u683c\u5316\u3057\u307e\u3057\u305f\u3002\u9854\u7528\u30af\u30ea\u30fc\u30e0\u306e\u30ec\u30c1\u30ce\u30fc\u30eb\u306f\u3001\u30ec\u30c1\u30ce\u30fc\u30eb\u5f53\u91cf\u3067\u6700\u59270.3%\u306b\u53b3\u3057\u304f\u5236\u9650\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3088\u308a\u901f\u3044\u7d50\u679c\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u30dc\u30c8\u30eb\u306b1.0%\u306e\u30ec\u30c1\u30ce\u30fc\u30eb\u3092\u8a70\u3081\u8fbc\u3080\u3060\u3051\u3067\u306f\u3082\u3046\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n

    \u3088\u308a\u8ce2\u304f\u914d\u5408\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u30d5\u30a7\u30eb\u30e9\u9178\u306f\u3053\u306e\u6709\u52b9\u6027\u306e\u30ae\u30e3\u30c3\u30d7\u3092\u57cb\u3081\u307e\u3059\u3002\u305d\u308c\u81ea\u4f53\u304c\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3068\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u52b9\u679c\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30ec\u30c1\u30ce\u30fc\u30eb\u3068\u306f\u5168\u304f\u7570\u306a\u308b\u7d4c\u8def\u304b\u3089\u3001\u8272\u7d20\u6c88\u7740\u306b\u5bfe\u51e6\u3057\u307e\u3059\u3002\u6d88\u8cbb\u8005\u306f\u3001\u6cd5\u7684\u306b\u6e96\u62e0\u3057\u305f0.3%\u30ec\u30c1\u30ce\u30fc\u30eb\u88fd\u54c1\u304b\u3089\u3001\u512a\u308c\u305f\u8996\u899a\u7684\u7d50\u679c\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n

    \u5f53\u793e\u306f\u3001\u9ad8\u7d14\u5ea6\u306e\u5929\u7136\u30d5\u30a7\u30eb\u30e9\u9178\u3068\u5b89\u5b9a\u5316\u3055\u308c\u305f\u30ec\u30c1\u30ce\u30fc\u30eb\u30b7\u30b9\u30c6\u30e0\u3092\u4e16\u754c\u4e2d\u306e\u5316\u7ca7\u54c1\u5de5\u5834\u306b\u4f9b\u7d66\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u958b\u767a\u30c1\u30fc\u30e0\u304c\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u5b89\u5b9a\u6027\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u5b9f\u884c\u3059\u308b\u305f\u3081\u306e\u8a66\u9a13\u30b5\u30f3\u30d7\u30eb\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u30c8\u30e9\u30a4\u30a2\u30eb\u6750\u6599\u304a\u3088\u3073\u7279\u6b8a\u6eb6\u5a92\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u30ea\u30af\u30a8\u30b9\u30c8\u3059\u308b\u306b\u306f\u3001\u5f53\u793e\u306e\u6280\u8853\u30c1\u30fc\u30e0\u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\u3002<\/p>\n\n

    \n\n

    \u53c2\u8003\u6587\u732e<\/h3>\n
      \n
    • SCCS\uff08\u6d88\u8cbb\u8005\u5b89\u5168\u79d1\u5b66\u59d4\u54e1\u4f1a\uff09\u3002(2022)\u3002\u30d3\u30bf\u30df\u30f3A\uff08\u30ec\u30c1\u30ce\u30fc\u30eb\u3001\u9162\u9178\u30ec\u30c1\u30cb\u30eb\u3001\u30d1\u30eb\u30df\u30c1\u30f3\u9178\u30ec\u30c1\u30cb\u30eb\uff09\u306b\u95a2\u3059\u308b\u79d1\u5b66\u7684\u610f\u898b\u306e\u6539\u8a02\u3002<\/li>\n
    • Zhai, H., et al. (2013)\u3002\u300c\u30d5\u30a7\u30eb\u30e9\u9178\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u7528\u9014\u306b\u304a\u3051\u308b\u53ef\u80fd\u6027\u300d\u3002 \u30b8\u30e3\u30fc\u30ca\u30eb\u30fb\u30aa\u30d6\u30fb\u30b3\u30b9\u30e1\u30c6\u30a3\u30c3\u30af\u30fb\u30c0\u30fc\u30de\u30c8\u30ed\u30b8\u30fc<\/em>.<\/li>\n
    • Graf, E. (1992)\u3002\u300c\u30d5\u30a7\u30eb\u30e9\u9178\u306e\u6297\u9178\u5316\u4f5c\u7528\u300d\u3002 \u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u30fb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u30fb\u30a2\u30f3\u30c9\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3<\/em>.<\/li>\n <\/ul>\n\n<\/div>","protected":false},"excerpt":{"rendered":"

      \u7d14\u7c8b\u306a\u7d50\u6676\u6027\u30ec\u30c1\u30ce\u30fc\u30eb\u3067\u306e\u88fd\u5264\u5316\u3092\u8a66\u307f\u308b\u306e\u306f\u3084\u3081\u307e\u3057\u3087\u3046\u3002\u7d14\u7c8b\u306a\u30ec\u30c1\u30ce\u30fc\u30eb\uff08\u7d14\u5ea698%\uff09\u306f\u975e\u5e38\u306b\u4e0d\u5b89\u5b9a\u3067\u3059\u3002\u9178\u7d20\u3001\u5149\u3001\u71b1\u306b\u3055\u3089\u3055\u308c\u308b\u3068\u6025\u901f\u306b\u5206\u89e3\u3057\u307e\u3059\u2026\u3002<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-15116","post","type-post","status-publish","format-standard","hentry","category-product-updates"],"yoast_head":"\nRetinol and Ferulic Acid: Overcoming Formulation Instability and Skin Irritation - Shaanxi Huatai Bio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.totarolchina.com\/ja\/retinol-and-ferulic-acid-overcoming-formulation-instability-and-skin-irritation\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Retinol and Ferulic Acid: Overcoming Formulation Instability and Skin Irritation\" \/>\n<meta property=\"og:description\" content=\"Stop trying to formulate with pure crystalline retinol. 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