{"id":15186,"date":"2026-09-02T09:00:38","date_gmt":"2026-09-02T09:00:38","guid":{"rendered":"https:\/\/www.totarolchina.com\/?p=15186"},"modified":"2026-09-02T09:00:40","modified_gmt":"2026-09-02T09:00:40","slug":"oxidative-stress-and-skin-aging-understanding-the-biological-connection","status":"publish","type":"post","link":"https:\/\/www.totarolchina.com\/ja\/oxidative-stress-and-skin-aging-understanding-the-biological-connection\/","title":{"rendered":"\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u76ae\u819a\u306e\u8001\u5316\uff1a\u751f\u7269\u5b66\u7684\u306a\u95a2\u9023\u6027\u306e\u7406\u89e3"},"content":{"rendered":"
\n

\n \u7d2b\u5916\u7dda\u3001\u5927\u6c17\u6c5a\u67d3\u3001\u305f\u3070\u3053\u306e\u7159<\/span> \u306f\u3001\u76ae\u819a\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5916\u7684\u8981\u56e0\u306e\u4e00\u90e8\u3067\u3059\u3002 \u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09<\/strong> \u306f\u3001\u901a\u5e38\u306e\u7d30\u80de\u4ee3\u8b1d\u4e2d\u306b\u3082\u751f\u6210\u3055\u308c\u307e\u3059\u3002\n <\/p>\n

\n \u76ae\u819a\u306b\u306f\u3001\u6d3b\u6027\u5206\u5b50\u3092\u5236\u5fa1\u4e0b\u306b\u4fdd\u3064\u306e\u306b\u5f79\u7acb\u3064\u72ec\u81ea\u306e\u6297\u9178\u5316\u9632\u5fa1\u6a5f\u69cb\u304c\u3042\u308a\u307e\u3059\u3002ROS\u3068\u6297\u9178\u5316\u80fd\u529b\u306e \u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u308b\u3068<\/span>\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u76ae\u819a\u306e\u8001\u5316\u3084\u5149\u8001\u5316\u306b\u304a\u3044\u3066\u7dbf\u5bc6\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n <\/p>\n\n \n

\n \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f\n <\/h2>\n

\n ROS\u306f\u3001\u4ee3\u8b1d\u3084\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u4e2d\u306b\u751f\u6210\u3055\u308c\u308b\u3001\u901a\u5e38\u306e\u76ae\u819a\u751f\u7269\u5b66\u306e\u4e00\u90e8\u3067\u3059\u3002\u7d30\u80de\u306f\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3092\u901a\u3058\u3066ROS\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u305d\u306e\u5b58\u5728\u304c\u5fc5\u305a\u3057\u3082\u640d\u50b7\u3092\u610f\u5473\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\n <\/p>\n

\n \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u9178\u5316\u6d3b\u6027\u304c\u3053\u308c\u3089\u306e\u9632\u5fa1\u80fd\u529b\u3092\u8d85\u3048\u308b\u5834\u5408\u306b\u61f8\u5ff5\u3068\u306a\u308a\u307e\u3059\u3002<\/strong> \u305d\u306e\u6642\u70b9\u3067\u3001\u8102\u8cea\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001DNA\u304c\u5f71\u97ff\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \n <\/p>\n

    \n
  • \u8102\u8cea\u904e\u9178\u5316\uff1a<\/span> \u7d30\u80de\u819c\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n
  • \u30bf\u30f3\u30d1\u30af\u8cea\u9178\u5316\uff1a<\/span> \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n
  • DNA\u640d\u50b7\uff1a<\/span> \u907a\u4f1d\u7269\u8cea\u3078\u306e\u9178\u5316\u640d\u50b7\u3002<\/li>\n <\/ul>\n\n \n

    \n \u6d3b\u6027\u9178\u7d20\u7a2e\u306f\u3069\u3053\u304b\u3089\u6765\u308b\u306e\u3067\u3059\u304b\uff1f\n <\/h2>\n

    ROS\u306f\u3001\u901a\u5e38\u306e\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3068\u74b0\u5883\u66dd\u9732\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n \n \n \n \n \n \n \n \n \n
    \u51fa\u5178<\/th>\n \u4f8b<\/th>\n <\/tr>\n <\/thead>\n
    \u74b0\u5883\u7684<\/td>\n \u7d2b\u5916\u7dda\u3001\u5927\u6c17\u6c5a\u67d3\u3001\u305f\u3070\u3053\u306e\u7159<\/td>\n <\/tr>\n
    \u751f\u7269\u5b66\u7684<\/td>\n \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4ee3\u8b1d\u3001\u708e\u75c7\u53cd\u5fdc<\/td>\n <\/tr>\n
    \u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb<\/td>\n \u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9\u3001\u7761\u7720\u4e0d\u8db3\u3001\u4e0d\u5065\u5eb7\u306a\u98df\u4e8b<\/td>\n <\/tr>\n
    \u7269\u7406\u7684<\/td>\n \u71b1\u3068\u74b0\u5883\u30b9\u30c8\u30ec\u30b9<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n

    \n \u7d2b\u5916\u7dda<\/span> \u306f\u3001\u76ae\u819a\u306b\u304a\u3051\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u4e3b\u306a\u539f\u56e0\u3067\u3059\u3002\u74b0\u5883\u8981\u56e0\u304c\u7d44\u307f\u5408\u308f\u3055\u308b\u3068\uff08\u4f8b\uff1a\u7d2b\u5916\u7dda\u3001\u71b1\u3001\u5927\u6c17\u6c5a\u67d3\uff09\u3001\u500b\u3005\u306e\u5f71\u97ff\u3092\u5206\u96e2\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u306b\u306a\u308a\u307e\u3059\u3002\n <\/p>\n\n \n

    \n \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u76ae\u819a\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3057\u307e\u3059\u304b\uff1f\n <\/h2>\n

    \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u7d30\u80de\u6210\u5206\u3068\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u3068\u30a8\u30e9\u30b9\u30c1\u30f3\u3092\u4ecb\u3057\u3066\u69cb\u9020\u7684\u30b5\u30dd\u30fc\u30c8\u3092\u63d0\u4f9b\u3059\u308b\uff09\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u5909\u5316\u306b\u306f\u4ee5\u4e0b\u304c\u542b\u307e\u308c\u307e\u3059\uff1a<\/p>\n

      \n
    • \u8102\u8cea\u904e\u9178\u5316<\/li>\n
    • \u30bf\u30f3\u30d1\u30af\u8cea\u9178\u5316<\/li>\n
    • DNA\u640d\u50b7<\/li>\n
    • \u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u4ee3\u8b1d\u306e\u5909\u5316<\/li>\n
    • \u4e00\u90e8\u306e\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMP\uff09\u306e\u6d3b\u6027\u5897\u52a0<\/span> \u2013 \u7d2b\u5916\u7dda\u66dd\u9732\u5f8c\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u9175\u7d20\u3002<\/li>\n <\/ul>\n\n \n

      \n \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u5149\u8001\u5316\n <\/h2>\n

      \n \u7d2b\u5916\u7dda\u66dd\u9732\u306f\u3001\u5149\u8001\u5316\u306e\u4e3b\u306a\u539f\u56e0\u3067\u3059\u3002ROS\u30ec\u30d9\u30eb\u3092\u4e0a\u6607\u3055\u305b\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3084\u708e\u75c7\u6d3b\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u3001\u3053\u308c\u3089\u306e\u7d2f\u7a4d\u7684\u306a\u53cd\u5fdc\u306f\u76ae\u819a\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u307e\u3059\u3002\u52a0\u9f62\u306b\u3088\u308b\u8001\u5316\u306f\u5185\u56e0\u6027\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e2\u3064\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u540c\u3058\u76ae\u819a\u3067\u767a\u751f\u3057\u3001\u76f8\u4e92\u4f5c\u7528\u3057\u307e\u3059\u3002\n <\/p>\n\n \n

      \n \u76ae\u819a\u306f\u3069\u306e\u3088\u3046\u306b\u81ea\u5df1\u9632\u5fa1\u3057\u307e\u3059\u304b\uff1f\n <\/h2>\n

      \u76ae\u819a\u306f\u3001\u9175\u7d20\u7684\u304a\u3088\u3073\u975e\u9175\u7d20\u7684\u306a\u6297\u9178\u5316\u7269\u8cea\u3092\u4f7f\u7528\u3057\u3066\u3001\u904e\u5270\u306a\u9178\u5316\u6d3b\u6027\u3092\u5236\u9650\u3057\u307e\u3059\u3002<\/p>\n \n \n \n \n \n \n \n \n \n \n
      \u9632\u5fa1\u30b7\u30b9\u30c6\u30e0<\/th>\n \u6a5f\u80fd<\/th>\n <\/tr>\n <\/thead>\n
      \u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\uff08SOD\uff09<\/td>\n \u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u3092\u904e\u9178\u5316\u6c34\u7d20\u3068\u9178\u7d20\u306b\u5909\u63db\u3057\u307e\u3059<\/td>\n <\/tr>\n
      \u30ab\u30bf\u30e9\u30fc\u30bc<\/td>\n \u904e\u9178\u5316\u6c34\u7d20\u3092\u5206\u89e3\u3057\u307e\u3059<\/td>\n <\/tr>\n
      \u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc<\/td>\n \u904e\u9178\u5316\u6c34\u7d20\u3068\u8102\u8cea\u30d2\u30c9\u30ed\u30da\u30eb\u30aa\u30ad\u30b7\u30c9\u3092\u9084\u5143\u3057\u307e\u3059<\/td>\n <\/tr>\n
      \u30d3\u30bf\u30df\u30f3C<\/td>\n \u6c34\u6eb6\u6027\u6297\u9178\u5316\u7269\u8cea<\/td>\n <\/tr>\n
      \u30d3\u30bf\u30df\u30f3E<\/td>\n \u8102\u6eb6\u6027\u6297\u9178\u5316\u7269\u8cea<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n\n \n

      \n \u306a\u305c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u5316\u7ca7\u54c1\u79d1\u5b66\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\n <\/h2>\n

      \n \u5b9f\u9a13\u5ba4\u8a66\u9a13\u3067\u306f\u3001\u6210\u5206\u304c\u6d3b\u6027\u7a2e\u3068\u53cd\u5fdc\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u6e2c\u5b9a\u3057\u3001\u6709\u7528\u306a\u5316\u5b66\u7684\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001 \u88fd\u5264\u6761\u4ef6<\/span> \uff08\u6fc3\u5ea6\u3001\u5b89\u5b9a\u6027\u3001\u9001\u9054\u306a\u3069\uff09\u306f\u3001\u6210\u5206\u306e\u6319\u52d5\u3092\u5909\u5316\u3055\u305b\u307e\u3059\u3002\u6297\u9178\u5316\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u88fd\u5264\u8a66\u9a13\u304a\u3088\u3073\u30d2\u30c8\u3067\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f75\u305b\u3066\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n <\/p>\n\n \n

      \n \u4eca\u5f8c\u306e\u7814\u7a76\u306e\u65b9\u5411\u6027\n <\/h2>\n

      \u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u6355\u6349\u306f\u3001\u73fe\u5728\u306e\u7814\u7a76\u5206\u91ce\u306e1\u3064\u306b\u3059\u304e\u307e\u305b\u3093\u3002\u305d\u306e\u4ed6\u306e\u30c8\u30d4\u30c3\u30af\u306b\u306f\u4ee5\u4e0b\u304c\u542b\u307e\u308c\u307e\u3059\uff1a<\/p>\n

        \n
      • \u30ec\u30c9\u30c3\u30af\u30b9\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/li>\n
      • \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd<\/li>\n
      • \u76ae\u819a\u30d0\u30ea\u30a2\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9<\/li>\n
      • \u76ae\u819a\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u76f8\u4e92\u4f5c\u7528<\/li>\n
      • \u74b0\u5883\u30a8\u30af\u30b9\u30dd\u30bd\u30fc\u30e0\u3068\u76ae\u819a\u306e\u5065\u5eb7<\/li>\n <\/ul>\n\n
        \n\n \n

        \u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n \n
        \n

        \u76ae\u819a\u306b\u304a\u3051\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/p>\n

        \u9178\u5316\u6d3b\u6027\u304c\u6297\u9178\u5316\u9632\u5fa1\u306b\u3088\u3063\u3066\u9069\u5207\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u306a\u3044\u72b6\u614b\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n <\/div>\n \n

        \n

        \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u76ae\u819a\u306e\u8001\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u304b\uff1f<\/p>\n

        \u76ae\u819a\u306e\u8001\u5316\u3084\u5149\u8001\u5316\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u95a2\u4e0e\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u8981\u56e0\u306e\u3046\u3061\u306e1\u3064\u306b\u3059\u304e\u307e\u305b\u3093\u3002<\/p>\n <\/div>\n\n

        \n

        \u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/p>\n

        ROS\u306f\u3001\u4ee3\u8b1d\u3084\u74b0\u5883\u66dd\u9732\u4e2d\u306b\u751f\u6210\u3055\u308c\u308b\u3001\u9178\u7d20\u3092\u542b\u3080\u53cd\u5fdc\u6027\u5206\u5b50\u3067\u3059\u3002\uff08\u6ce8\uff1a\u4e00\u90e8\u306f\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3067\u3059\u304c\u3001\u904e\u9178\u5316\u6c34\u7d20\u306f\u305d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff09\u3002<\/p>\n <\/div>\n\n

        \n

        \u7d2b\u5916\u7dda\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u304b\uff1f<\/p>\n

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        \n

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          \n
        1. \u30b7\u30fc\u30b9 H. \u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff1a\u30ec\u30c9\u30c3\u30af\u30b9\u751f\u7269\u5b66\u3068\u533b\u5b66\u306b\u304a\u3051\u308b\u6982\u5ff5\u3002<\/em> \u30ec\u30c9\u30c3\u30af\u30b9\u751f\u7269\u5b66\u30022015;4:180\u2013183\u3002<\/li>\n
        2. \u30ea\u30f3\u30cd\u30bf\u30fc\u30e9\u30fc M, \u30d3\u30b7\u30e7\u30d5 J, \u30b7\u30e5\u30c8\u30a4\u30d9\u30eb MK, \u30c8\u30ed\u30b9\u30c8 A, \u30ea\u30d2\u30bf\u30fc K. \u8001\u5316\u30d2\u30c8\u76ae\u819a\u306b\u304a\u3051\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3002<\/em> \u751f\u4f53\u5206\u5b50\u30022015;5(2):545\u2013589\u3002<\/li>\n
        3. \u30d4\u30e9\u30a4 S, \u30aa\u30ec\u30b5\u30db C, \u30d8\u30a4\u30ef\u30fc\u30c9 J. \u7d2b\u5916\u7dda\u3068\u76ae\u819a\u306e\u8001\u5316\uff1a\u6d3b\u6027\u9178\u7d20\u7a2e\u3001\u708e\u75c7\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u306e\u5f79\u5272\u2026<\/em> \u56fd\u969b\u5316\u7ca7\u54c1\u79d1\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb\u30022005;27(1):17\u201334\u3002<\/li>\n
        4. \u30dd\u30eb\u30b7\u30e3\u30af B, \u30c0\u30cf\u30e1 R. \u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3068\u5916\u56e0\u6027\u76ae\u819a\u8001\u5316\u3002<\/em> \u76ae\u819a\u79d1\u7814\u7a76\u3068\u5b9f\u8df5\u30022012;2012:135206\u3002<\/li>\n
        5. \u30d0\u30fc\u30af KE. \u8001\u5316\u3068\u767a\u9054\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u2014\u76ae\u819a\u3078\u306e\u74b0\u5883\u30c0\u30e1\u30fc\u30b8\u306e\u65b0\u305f\u306a\u7406\u89e3\u3068\u5c40\u6240\u6297\u9178\u5316\u7269\u8cea\u306b\u3088\u308b\u4e88\u9632\u3002<\/em> \u8001\u5316\u3068\u767a\u9054\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u30022018;172:123\u2013130\u3002<\/li>\n <\/ol>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

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