{"id":15245,"date":"2026-09-22T09:32:59","date_gmt":"2026-09-22T09:32:59","guid":{"rendered":"https:\/\/www.totarolchina.com\/?p=15245"},"modified":"2026-09-22T09:33:00","modified_gmt":"2026-09-22T09:33:00","slug":"bakuchiol-vs-pdrn-clinical-efficacy-and-formulation-parameters","status":"publish","type":"post","link":"https:\/\/www.totarolchina.com\/ja\/bakuchiol-vs-pdrn-clinical-efficacy-and-formulation-parameters\/","title":{"rendered":"\u30d0\u30af\u30c1\u30aa\u30fc\u30eb vs PDRN\uff1a\u81e8\u5e8a\u52b9\u679c\u3068\u88fd\u5264\u30d1\u30e9\u30e1\u30fc\u30bf"},"content":{"rendered":"<div style=\"max-width: 100%; font-family: 'Helvetica Neue', Arial, sans-serif; line-height: 1.8; color: #2c3e50; background-color: #ffffff; padding: 20px; box-sizing: border-box;\">\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    \u771f\u76ae\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u518d\u69cb\u7bc9\u306f\u5f53\u3066\u305a\u3063\u307d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u7279\u5b9a\u306e\u751f\u5316\u5b66\u7684\u7d4c\u8def\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002\u6d3b\u6027\u5206\u5b50\u3092\u5c0e\u5165\u3059\u308b\u3068\u3001\u76ae\u819a\u304c\u53cd\u5fdc\u3057\u307e\u3059\u3002\u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u306f\u30ec\u30c1\u30ce\u30fc\u30eb\u3092\u6a21\u5023\u3057\u307e\u3059\u3002PDRN\u306f\u30a2\u30c7\u30ce\u30b7\u30f3\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u7d44\u7e54\u3092\u518d\u751f\u3057\u307e\u3059\u30022\u3064\u306e\u7570\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3002\u305d\u308c\u3089\u306e\u7269\u7406\u5316\u5b66\u7684\u7279\u6027\u3092\u4e26\u3079\u3066\u8a55\u4fa1\u3059\u308b\u3068\u3001\u5b9f\u969b\u306e\u88fd\u5264\u4e0a\u306e\u5236\u7d04\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3059\u3002\u30cf\u30fc\u30c9\u30c7\u30fc\u30bf\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\n  <\/p>\n\n  <h2 style=\"color: #2471a3; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u7d4c\u8def\u6d3b\u6027\u5316\u3068\u81e8\u5e8a\u7684\u73fe\u5b9f<\/h2>\n\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    \u306a\u305c\u4e00\u65b9\u3067\u306f\u306a\u304f\u4ed6\u65b9\u3092\u9078\u3076\u306e\u304b\uff1f\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u9069\u7528\u65b9\u6cd5\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002\u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u306f\u3001\u771f\u76ae\u8868\u76ae\u63a5\u5408\u90e8\u306e\u69cb\u9020\u7684\u52a3\u5316\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u3002CRBP-1\u3084RARE\u306e\u3088\u3046\u306a\u30ec\u30c1\u30ce\u30fc\u30eb\u8a98\u5c0e\u907a\u4f1d\u5b50\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u53d7\u5bb9\u4f53\u306b\u89e6\u308c\u308b\u3053\u3068\u306a\u304f\u884c\u308f\u308c\u307e\u3059\u3002\u5178\u578b\u7684\u306a\u30ec\u30c1\u30ce\u30a4\u30c9\u306e\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u56de\u907f\u3057\u307e\u3059\u3002 <strong style=\"color: #c0392b; font-weight: 600;\">\u81e8\u5e8a\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3067\u306f\u30010.5%\u306e\u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\u304c\u30011\u65e52\u56de\u306e\u5857\u5e03\u309212\u9031\u9593\u884c\u3063\u305f\u7d50\u679c\u3001\u3057\u308f\u306e\u6df1\u3055\u309220.5%\u8efd\u6e1b\u3057\u3001\u8272\u7d20\u6c88\u7740\u306e\u5f37\u5ea6\u309259%\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><span style=\"color: #2980b9;\">[\u30d6\u30ea\u30c6\u30a3\u30c3\u30b7\u30e5\u30fb\u30b8\u30e3\u30fc\u30ca\u30eb\u30fb\u30aa\u30d6\u30fb\u30c0\u30fc\u30de\u30c8\u30ed\u30b8\u30fc\uff1a\u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u306b\u3088\u308b\u76ae\u819a\u8001\u5316\u7279\u6027\u306e\u8a55\u4fa1 \u2013 https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/bjd.16918]<\/span> \n  <\/p>\n\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    PDRN\u306f\u7570\u306a\u308b\u50cd\u304d\u3092\u3057\u307e\u3059\u3002\u30b5\u30eb\u30d9\u30fc\u30b8\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002DNA\u5408\u6210\u306e\u305f\u3081\u306e\u7279\u5b9a\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u524d\u99c6\u4f53\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u30a2\u30c7\u30ce\u30b7\u30f3A2A\u53d7\u5bb9\u4f53\u306b\u9078\u629e\u7684\u306b\u7d50\u5408\u3057\u307e\u3059\u3002\u3053\u306e\u7d50\u5408\u306f\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\uff08VEGF\uff09\u306e\u653e\u51fa\u3092\u30c8\u30ea\u30ac\u30fc\u3057\u307e\u3059\u3002\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u5897\u6b96\u304c\u6025\u5897\u3057\u307e\u3059\u3002 <strong style=\"color: #c0392b; font-weight: 600;\">invitro\u7d30\u80de\u751f\u5b58\u7387\u30a2\u30c3\u30bb\u30a4\u3067\u306f\u3001100 \u03bcg\/mL\u306ePDRN\u304c\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u306648\u6642\u9593\u4ee5\u5185\u306b\u30d2\u30c8\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u751f\u5b58\u7387\u309232%\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><span style=\"color: #2980b9;\">[\u30a4\u30f3\u30bf\u30fc\u30ca\u30b7\u30e7\u30ca\u30eb\u30fb\u30b8\u30e3\u30fc\u30ca\u30eb\u30fb\u30aa\u30d6\u30fb\u30e2\u30ec\u30ad\u30e5\u30e9\u30fc\u30fb\u30b5\u30a4\u30a8\u30f3\u30b7\u30ba\uff1a\u30dd\u30ea\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08PDRN\uff09\u306f\u5275\u50b7\u6cbb\u7652\u3092\u4fc3\u9032\u3059\u308b \u2013 https:\/\/www.mdpi.com\/1422-0067\/17\/3\/350]<\/span> \u5275\u50b7\u6cbb\u7652\u3092\u52a0\u901f\u3057\u307e\u3059\u3002\u771f\u76ae\u3092\u539a\u304f\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u8868\u9762\u306e\u5fae\u8abf\u6574\u3067\u306f\u306a\u304f\u3001\u57fa\u672c\u7684\u306a\u7d44\u7e54\u4fee\u5fa9\u3067\u3059\u3002\n  <\/p>\n\n  <h2 style=\"color: #2471a3; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u4ed5\u69d8\u30d1\u30e9\u30e1\u30fc\u30bf\u3068COA\u30d9\u30f3\u30c1\u30de\u30fc\u30af<\/h2>\n\n  <p style=\"font-size: 16px; margin-bottom: 15px;\">\n    \u54c1\u8cea\u7ba1\u7406\u306b\u306f\u5fb9\u5e95\u7684\u306a\u5206\u6790\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3059\u3002\u30d7\u30ec\u30df\u30a2\u30e0\u30b0\u30ec\u30fc\u30c9\u306e\u539f\u6750\u6599\u306f\u3053\u308c\u3089\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u59a5\u5354\u306f\u8a31\u3055\u308c\u307e\u305b\u3093\u3002\n  <\/p>\n\n  <div style=\"overflow-x: auto; margin-bottom: 25px;\">\n    <table style=\"width: 100%; border-collapse: collapse; font-size: 15px; text-align: left;\">\n      <thead>\n        <tr style=\"background-color: #ebedef; color: #2c3e50;\">\n          <th style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u8a66\u9a13\u9805\u76ee<\/th>\n          <th style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u30d1\u30e9\u30e1\u30fc\u30bf<\/th>\n          <th style=\"padding: 12px; border: 1px solid #bdc3c7;\">PDRN\uff08\u30dd\u30ea\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09<\/th>\n          <th style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u8a66\u9a13\u65b9\u6cd5\/\u5099\u8003<\/th>\n        <\/tr>\n      <\/thead>\n      <tbody>\n        <tr>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7; font-weight: bold;\">\u5916\u89b3<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u9ec4\u8272\u304b\u3089\u8336\u8272\u306e\u7c98\u6027\u6db2\u4f53<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u767d\u8272\u304b\u3089\u30aa\u30d5\u30db\u30ef\u30a4\u30c8\u306e\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u76ee\u8996\u691c\u67fb<\/td>\n        <\/tr>\n        <tr style=\"background-color: #f8f9f9;\">\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7; font-weight: bold;\">\u7d14\u5ea6\/\u30a2\u30c3\u30bb\u30a4<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7; color: #c0392b; font-weight: bold;\">99.0%\u4ee5\u4e0a<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7; color: #c0392b; font-weight: bold;\">\u2265 95.0%\uff08DNA\u542b\u6709\u91cf\uff09<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">HPLC \/ UV\u5206\u5149\u5149\u5ea6\u6cd5<\/td>\n        <\/tr>\n        <tr>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7; font-weight: bold;\">\u5206\u5b50\u91cf<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">256.38 g\/mol<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">50 kDa \u2013 1500 kDa\uff08\u30dd\u30ea\u30de\u30fc\uff09<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u30b2\u30eb\u6d78\u900f\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc<\/td>\n        <\/tr>\n        <tr style=\"background-color: #f8f9f9;\">\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7; font-weight: bold;\">\u6eb6\u89e3\u6027<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u975e\u5e38\u306b\u6cb9\u6eb6\u6027\u3001\u6c34\u4e0d\u6eb6\u6027<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u975e\u5e38\u306b\u6c34\u6eb6\u6027\u3001\u8102\u8cea\u4e0d\u6eb6\u6027<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">USP\u57fa\u6e96<\/td>\n        <\/tr>\n        <tr>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7; font-weight: bold;\">\u30bd\u30e9\u30ec\u30f3\u542b\u6709\u91cf<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">1 ppm\u672a\u6e80<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">N\/A<\/td>\n          <td style=\"padding: 12px; border: 1px solid #bdc3c7;\">\u5149\u5b89\u5168\u6027\u306b\u4e0d\u53ef\u6b20<\/td>\n        <\/tr>\n      <\/tbody>\n    <\/table>\n  <\/div>\n\n  <h2 style=\"color: #2471a3; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u88fd\u5264\u4e0a\u306e\u5236\u7d04\uff1a\u30e9\u30dc\u306e\u73fe\u5b9f<\/h2>\n\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    \u3053\u308c\u3089\u306e\u6d3b\u6027\u6210\u5206\u3092\u7d71\u5408\u3059\u308b\u3053\u3068\u306f\u672c\u8cea\u7684\u306b\u56f0\u96e3\u3067\u3059\u3002\u88fd\u9020\u74b0\u5883\u306f\u53b3\u5bc6\u306b\u7ba1\u7406\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \n  <\/p>\n\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    \u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u306f\u5149\u3092\u5acc\u3044\u307e\u3059\u3002\u5bb9\u6613\u306b\u5206\u89e3\u3057\u307e\u3059\u3002\u9077\u79fb\u91d1\u5c5e\u306f\u6025\u901f\u306a\u9178\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u88fd\u5264\u62c5\u5f53\u8005\u306f\u5f37\u529b\u306a\u9244\u30ad\u30ec\u30fc\u30c8\u5264\u3092\u4f7f\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u30b8\u30ca\u30c8\u30ea\u30a6\u30e0EDTA\u30920.05\u301c0.1%\u3067\u8003\u3048\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u306b\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\u306e\u3088\u3046\u306a\u5f37\u529b\u306a\u8102\u6eb6\u6027\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u3092\u7d44\u307f\u5408\u308f\u305b\u307e\u3059\u3002\u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u306f\u6cb9\u76f8\u306b\u5165\u308c\u307e\u3059\u3002\u51b7\u5374\u4e2d\u306b40\u00b0C\u672a\u6e80\u3067\u6295\u5165\u3057\u307e\u3059\u3002 <strong style=\"color: #d35400;\">\u904e\u5ea6\u306e\u71b1\u306f\u6d3b\u6027\u5206\u5b50\u3092\u7834\u58ca\u3057\u307e\u3059\u3002<\/strong> \u6700\u7d42\u51e6\u65b9\u306epH\u3092\u53b3\u5bc6\u306b4.0\u304b\u30895.5\u306e\u9593\u306b\u4fdd\u3061\u307e\u3059\u3002\n  <\/p>\n\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    PDRN\u306f\u3069\u3046\u3067\u3059\u304b\uff1f\u305d\u308c\u306f\u751f\u4f53\u9ad8\u5206\u5b50\u3067\u3059\u3002\u30ec\u30aa\u30ed\u30b8\u30fc\u304c\u6700\u5927\u306e\u8ab2\u984c\u3067\u3059\u3002\u9ad8\u305b\u3093\u65ad\u6df7\u5408\u3092\u4f7f\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002 <strong style=\"color: #d35400;\">3000 RPM\u3092\u8d85\u3048\u308b\u30db\u30e2\u30b8\u30ca\u30a4\u30b6\u30fc\u306f\u3001DNA\u65ad\u7247\u3092\u7269\u7406\u7684\u306b\u305b\u3093\u65ad\u3057\u307e\u3059\u3002<\/strong> \u5206\u5b50\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u53d7\u5bb9\u4f53\u89aa\u548c\u6027\u3092\u5931\u3044\u307e\u3059\u3002\u5468\u56f2\u6e29\u5ea6\u3067\u6c34\u76f8\u306b\u6df7\u5408\u3057\u307e\u3059\u3002pH\u30925.5\u4ee5\u4e0a\u306b\u4fdd\u3061\u307e\u3059\u3002\u9178\u6027\u74b0\u5883\u306fDNA\u306e\u8131\u30d7\u30ea\u30f3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u69cb\u9020\u5d29\u58ca\u304c\u7d9a\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u5f37\u529b\u306a\u30ab\u30c1\u30aa\u30f3\u6027\u30dd\u30ea\u30de\u30fc\u304b\u3089\u9060\u3056\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u8ca0\u306b\u5e2f\u96fb\u3057\u305f\u30dd\u30ea\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9396\u306f\u5373\u5ea7\u306b\u6c88\u6bbf\u3057\u307e\u3059\u3002\n  <\/p>\n\n  <h2 style=\"color: #2471a3; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u76f8\u4e57\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff1a\u73fe\u5728\u306e\u88fd\u5264\u30c8\u30ec\u30f3\u30c9<\/h2>\n\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    \u5358\u4e00\u6210\u5206\u306e\u51e6\u65b9\u306f\u6025\u901f\u306b\u8870\u9000\u3057\u3066\u3044\u307e\u3059\u3002\u30b0\u30ed\u30fc\u30d0\u30eb\u5e02\u5834\u306f\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u4fee\u5fa9\u30fb\u523a\u6fc0\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3092\u8981\u6c42\u3057\u3066\u3044\u307e\u3059\u3002 \n  <\/p>\n\n  <p style=\"font-size: 16px; margin-bottom: 20px;\">\n    <strong style=\"color: #16a085; font-size: 18px;\">\u30de\u30c8\u30ea\u30c3\u30af\u30b9A\uff1a\u690d\u7269\u7531\u6765\u30ec\u30c1\u30ce\u30fc\u30eb\uff0b\u30d0\u30ea\u30a2\u9632\u5fa1<\/strong><br>\n    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margin-bottom: 15px;\">\u898f\u5236\u304a\u3088\u3073\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u72b6\u6cc1<\/h2>\n\n  <p style=\"font-size: 16px; margin-bottom: 25px;\">\n    \u30b0\u30ed\u30fc\u30d0\u30eb\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306f\u3001\u5fae\u91cf\u6c5a\u67d3\u7269\u8cea\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u3066\u3044\u307e\u3059\u3002\u30d0\u30af\u30c1\u30aa\u30fc\u30eb\u306f\u304b\u3089\u62bd\u51fa\u3055\u308c\u307e\u3059 <i>\u30aa\u30e9\u30f3\u30c0\u30d3\u30e6<\/i>\u3002\u3053\u308c\u306f\u3001\u5149\u6bd2\u6027\u306e\u3042\u308b\u30bd\u30e9\u30ec\u30f3\u3092\u5171\u62bd\u51fa\u3059\u308b\u30ea\u30b9\u30af\u304c\u81ea\u7136\u306b\u3042\u308a\u307e\u3059\u3002 <strong style=\"color: #c0392b;\">\u9ad8\u30b0\u30ec\u30fc\u30c9\u306e\u6750\u6599\u306f\u3001\u30bd\u30e9\u30ec\u30f3\u30ec\u30d9\u30eb\u304c1 ppm\u672a\u6e80\u3067\u3042\u308b\u3053\u3068\u3092\u8a3c\u660e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/strong> 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