{"id":15323,"date":"2026-10-29T08:20:15","date_gmt":"2026-10-29T08:20:15","guid":{"rendered":"https:\/\/www.totarolchina.com\/?p=15323"},"modified":"2026-10-29T08:20:16","modified_gmt":"2026-10-29T08:20:16","slug":"alpha-arbutin-niacinamide-are-they-the-ultimate-formula-synergy","status":"publish","type":"post","link":"https:\/\/www.totarolchina.com\/ja\/alpha-arbutin-niacinamide-are-they-the-ultimate-formula-synergy\/","title":{"rendered":"\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\uff1a\u7a76\u6975\u306e\u51e6\u65b9\u30b7\u30ca\u30b8\u30fc\u304b\uff1f"},"content":{"rendered":"
\n\n

\n \u76ae\u819a\u306e\u8272\u7d20\u6c88\u7740\u6291\u5236\u306b\u306f\u591a\u89d2\u7684\u306a\u4ecb\u5165\u304c\u5fc5\u8981\u3067\u3059\u3002 \u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3 (INCI: Alpha-Arbutin)<\/span> \u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u7af6\u5408\u7684\u306b\u3002L-DOPA\u304b\u3089DOPA\u30ad\u30ce\u30f3\u3078\u306e\u5909\u63db\u3092\u76f4\u63a5\u30d6\u30ed\u30c3\u30af\u3057\u307e\u3059\u3002\u81e8\u5e8a\u5206\u96e2\u8a66\u9a13\u3067\u306f\u3001IC50\u304c\u7d041.0\uff5e1.2 mM\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002 [\u30b8\u30e3\u30fc\u30ca\u30eb\u30fb\u30aa\u30d6\u30fb\u30a4\u30f3\u30d9\u30b9\u30c6\u30a3\u30b2\u30a4\u30c6\u30a3\u30d6\u30fb\u30c0\u30fc\u30de\u30c8\u30ed\u30b8\u30fc]<\/span>\u6a19\u6e96\u7684\u306a\u88fd\u5264\u95be\u5024\u3067\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u7d30\u80de\u6bd2\u6027\u306f\u30bc\u30ed\u3067\u3059\u3002\n <\/p>\n\n

\n \u6b21\u306b\u3001 \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9 (INCI: Niacinamide)<\/span>\u304c\u3042\u308a\u307e\u3059\u3002 \u5b8c\u5168\u306b\u7570\u306a\u308b\u904b\u52d5\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306b\u5f71\u97ff\u3057\u307e\u3059\u304b\uff1f\u3044\u3044\u3048\u3002PAR-2\u53d7\u5bb9\u4f53\u3092\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u79fb\u884c\u304c\u7269\u7406\u7684\u306b\u906e\u65ad\u3055\u308c\u307e\u3059\u3002in vitro\u3067\u306e\u9084\u5143\u7387\u306f35%\uff5e68%\u306b\u9054\u3057\u307e\u3059\u3002<\/span>[British Journal of Dermatology]\n <\/p>\n\n \n

\u7269\u7406\u5316\u5b66\u7684\u57fa\u6e96\u5024<\/h2>\n

\u7269\u7406\u5316\u5b66\u7684\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n \n

\n \n \n \n \n \n \n \n \n \n \n
\u4ed5\u69d8\u30d1\u30e9\u30e1\u30fc\u30bf<\/th>\n \u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3<\/th>\n \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/th>\n <\/tr>\n <\/thead>\n
INCI\u540d<\/td>\n \u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3<\/td>\n \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/td>\n <\/tr>\n
CAS\u756a\u53f7<\/td>\n 84380-01-8<\/td>\n 98-92-3<\/td>\n <\/tr>\n
\u7d14\u5ea6\uff08HPLC\uff09<\/td>\n >= 99.0%<\/td>\n >= 99.5%<\/td>\n <\/tr>\n
\u5916\u89b3<\/td>\n \u767d\u8272\u7d50\u6676\u6027\u7c89\u672b<\/td>\n \u767d\u8272\u7d50\u6676\u6027\u7c89\u672b<\/td>\n <\/tr>\n
\u6700\u9069pH\u7bc4\u56f2<\/td>\n 4.5 – 6.5<\/td>\n 5.0 – 7.0<\/td>\n <\/tr>\n
\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u542b\u6709\u91cf<\/td>\n <= 1 ppm<\/td>\n N\/A<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n \n

\u51e6\u65b9\u8005\u306f\u53b3\u5bc6\u306a\u518d\u73fe\u6027\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002\u7269\u7406\u5316\u5b66\u7684\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306b\u6ce8\u76ee\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u3053\u306b\u53b3\u5bc6\u306a\u30c7\u30fc\u30bf\u304c\u3042\u308a\u307e\u3059\u3002<\/h2>\n

\n \u88fd\u5264\u30a2\u30fc\u30ad\u30c6\u30af\u30c1\u30e3\u3068\u30d7\u30ed\u30bb\u30b9\u5236\u5fa1 \u88fd\u5264\u306f\u53b3\u5bc6\u306a\u30d0\u30e9\u30f3\u30b9\u8abf\u6574\u3067\u3059\u3002\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u03b1-\u30b0\u30ea\u30b3\u30b7\u30c9\u7d50\u5408\u306f\u3001pH\u306b\u975e\u5e38\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002pH\u30924.0\u672a\u6e80\u306b\u3059\u308b\u3068\u3069\u3046\u306a\u308a\u307e\u3059\u304b\uff1f\u81ea\u767a\u7684\u306a\u52a0\u6c34\u5206\u89e3\u304c\u767a\u751f\u3057\u307e\u3059\u3002\u5371\u967a\u306a\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u304c\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u305d\u308c\u306f\u30ea\u30b9\u30af\u3067\u304d\u307e\u305b\u3093\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3082\u6975\u7aef\u306a\u6761\u4ef6\u4e0b\u3067\u306f\u540c\u69d8\u306b\u654f\u611f\u3067\u3059\u3002\u9ad8\u30a2\u30eb\u30ab\u30ea\u6027\u304a\u3088\u3073\u9ad8\u9178\u6027\u306e\u4e21\u65b9\u306e\u74b0\u5883\u304c\u52a0\u6c34\u5206\u89e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u526f\u751f\u6210\u7269\u306f\u30cb\u30b3\u30c1\u30f3\u9178\u3067\u3059\u3002\u6025\u6027\u306e\u76ae\u819a\u8840\u7ba1\u62e1\u5f35\u304c\u7d9a\u304d\u307e\u3059\u3002\u91cd\u8907\u306b\u3088\u308a\u3001\u30d0\u30eb\u30af\u88fd\u5264\u306epH\u30bf\u30fc\u30b2\u30c3\u30c8\u304c\u72ed\u307e\u308a\u307e\u3059\u3002<\/span> 5\u304b\u30896.0\u306e\u9593\u306b\u53b3\u5bc6\u306b\u7de9\u885d\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/span>.\n <\/p>\n\n

\n [International Journal of Cosmetic Science] \u71b1\u30b9\u30c8\u30ec\u30b9\u306f\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u3092\u7834\u58ca\u3057\u307e\u3059\u3002\u51b7\u6c34\u3067\u306e\u7d44\u307f\u8fbc\u307f\u3092\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u30d0\u30c3\u30c1\u6e29\u5ea6\u306f\u7dad\u6301\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059<\/span> 40 C\u672a\u6e80\n <\/p>\n\n \n

\u6700\u7d42\u7684\u306a\u5747\u8cea\u5316\u306e\u524d\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3088\u308a\u591a\u304f\u306e\u71b1\u3092\u51e6\u7406\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5206\u89e3\u306e\u30ea\u30b9\u30af\u3092\u5192\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304b\uff1f\u51b7\u5374\u6bb5\u968e\u3067\u8ffd\u52a0\u3057\u307e\u3059\u3002<\/h2>\n

\u9ad8\u5ea6\u306a\u76f8\u4e57\u30de\u30c8\u30ea\u30c3\u30af\u30b9<\/p>\n\n

\n \n \n \n \n \n \n \n
\u76f8<\/th>\n INCI\u540d<\/th>\n \u7814\u7a76\u958b\u767a\u306f\u4e8c\u5143\u30b7\u30b9\u30c6\u30e0\u3092\u8d85\u3048\u307e\u3057\u305f\u3002\u5c40\u6240\u7684\u306a\u751f\u4f53\u5229\u7528\u80fd\u304c\u5fc5\u8981\u3067\u3059\u3002<\/th>\n \u6a5f\u80fd<\/th>\n <\/tr>\n <\/thead>\n
\u6bd4\u7387<\/td>\n \u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3<\/td>\n 1.0% – 2.0%<\/td>\n \u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3<\/td>\n <\/tr>\n
\u6bd4\u7387<\/td>\n \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/td>\n 3.0% – 5.0%<\/td>\n \u6c34 (A)<\/td>\n <\/tr>\n
\u8ee2\u9001\u306e\u4e2d\u65ad<\/td>\n \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3<\/td>\n 0.05% – 0.1%<\/td>\n \u6dfb\u52a0\u5264 (C)<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n \n
\n

\n TRP-1\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<\/strong> \u9ad8\u7d14\u5ea6\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3 (INCI: Glabridin): \u7d14\u7c8b\u306a\u767d\u3044\u7c89\u672b\u3068\u3057\u3066\u5b58\u5728\u3057\u307e\u3059\u3002\u9069\u5207\u306b\u8abf\u9054\u3055\u308c\u308b\u3068\u3001\u8fc5\u901f\u306aTRP-1\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30bf\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u30ea\u30dd\u30bd\u30fc\u30e0\u306b\u5c01\u5165\u3057\u307e\u3059\u3002\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306b\u3088\u3063\u3066\u958b\u59cb\u3055\u308c\u305f\u9175\u7d20\u963b\u5bb3\u3092\u5287\u7684\u306b\u5f37\u5316\u3057\u307e\u3059\u3002<\/span>.\n <\/p>\n

\n [Phytomedicine]<\/strong> \u30c8\u30bf\u30ed\u30fc\u30eb (INCI: Totarol): \u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u904e\u5270\u306b\u5bfe\u51e6\u3057\u3066\u3044\u307e\u3059\u304b\uff1f\u30c8\u30bf\u30ed\u30fc\u30eb\u306f\u30a2\u30af\u30cd\u83cc\u3092\u7a4d\u6975\u7684\u306b\u963b\u5bb3\u3057\u307e\u3059\u3002<\/span>MIC\u306f0.78\uff5e1.56 ug\/mL\u3067\u3059\u3002 \u30cb\u30ad\u30d3\u8a98\u767a\u6027\u8272\u7d20\u306e\u751f\u7269\u5b66\u7684\u6839\u6e90\u3092\u4e2d\u548c\u3057\u307e\u3059\u3002<\/span>.\n <\/p>\n

\n [Journal of Antimicrobial Chemotherapy]<\/strong> \u30d7\u30c6\u30ed\u30b9\u30c1\u30eb\u30d9\u30f3 (INCI: Pterocarpus Marsupium Bark Extract): \u304b\u3089\u62bd\u51fa\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/span>\u30d7\u30c6\u30ed\u30ab\u30eb\u30d7\u30b9\u6a39\u76ae \u975e\u5e38\u306b\u89aa\u6cb9\u6027\u3067\u3059\u3002\u30a8\u30ea\u30fc\u30c8\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u30b9\u30ab\u30d9\u30f3\u30b8\u30e3\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u9ed2\u8272\u5316\u306e\u9023\u9396\u53cd\u5fdc\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u524d\u306b\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u7d4c\u8def\u3092\u5206\u89e3\u3057\u307e\u3059\u3002<\/span>.\n <\/p>\n <\/div>\n\n \n

[Journal of Agricultural and Food Chemistry]<\/h2>\n

\n \u898f\u5236\u9075\u5b88\u306e\u5236\u9650 \u898f\u5236\u4e0a\u306e\u5b89\u5168\u6027\u306f\u7d76\u5bfe\u3067\u3059\u3002SCCS\u306f\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306b\u53b3\u3057\u3044\u5236\u9650\u3092\u8ab2\u3057\u3066\u3044\u307e\u3059\u3002<\/span> \u9854\u7528\u30b1\u30a2\u3067\u306f2.0%\u3002\u30dc\u30c7\u30a3\u30b1\u30a2\u3067\u306f0.5%\u3002 \u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u30ec\u30d9\u30eb\u306f1 ppm\u672a\u6e80\u3067\u3042\u308b\u3053\u3068\u304c\u691c\u8a3c\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6307\u6a19\u306b\u5931\u6557\u3057\u305f\u5834\u5408\u3001\u5373\u6642\u306e\u5e02\u5834\u56de\u53ce\u306e\u6e96\u5099\u3092\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/span>.\n <\/p>\n\n \n

[European Commission SCCS Guidelines]<\/h2>\n \n
\n
\n B2B\u8abf\u9054\u306b\u95a2\u3059\u308b\u30c8\u30c3\u30d78\u306eFAQ<\/strong>\n \u6b8b\u7559\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u6700\u5927\u8a31\u5bb9\u5024\u306f\u3044\u304f\u3064\u3067\u3059\u304b\uff1f<\/span>\n <\/div>\n\n
\n HPLC\u306b\u3088\u308b1 ppm\u4ee5\u4e0b\u306e\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u306eCOA\u691c\u8a3c\u3092\u8981\u6c42\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u306f\u53b3\u683c\u306a\u4e16\u754c\u7684\u306a\u76ae\u819a\u79d1\u5b66\u7684\u5b89\u5168\u6027\u6307\u4ee4\u3067\u3059\u3002<\/strong>\n \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u6c34\u4e2d\u3067\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u52a0\u6c34\u5206\u89e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u304b\uff1f<\/span>\n <\/div>\n\n
\n \u3044\u3044\u3048\u3002\u5316\u5b66\u7684\u9069\u5408\u6027\u306f\u826f\u597d\u3067\u3059\u3002\u6700\u7d42\u7684\u306a\u30d0\u30eb\u30af\u88fd\u5264\u306epH\u30925.5\u304b\u30896.0\u306e\u9593\u306b\u7d99\u7d9a\u7684\u306b\u7de9\u885d\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong>\n \u3053\u308c\u3089\u306f\u30b3\u30fc\u30eb\u30c9\u30d7\u30ed\u30bb\u30b9\u4e73\u5316\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059\u304b\uff1f<\/span>\n <\/div>\n\n
\n \u306f\u3044\u3002\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306f151 g\/L\u3067\u9ad8\u3044\u51b7\u6c34\u6eb6\u89e3\u5ea6\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u6e29\u5ea6\u306b\u654f\u611f\u306a\u52a0\u5de5\u306b\u6700\u9069\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/strong>\n \u6a19\u6e96\u7684\u306a\u6fc3\u5ea6\u6bd4\u306f\u3069\u306e\u304f\u3089\u3044\u3067\u3059\u304b\uff1f<\/span>\n <\/div>\n\n
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