Niacinamide

Chemical Structure & Properties

Niacinamide (nicotinamide) is the amide form of vitamin B3 (niacin). Its pyridine ring structure enables diverse biological functions. Unlike niacin, it doesn’t cause flushing. Stable in pH range 5-7, heat-resistant up to 40°C, and compatible with most cosmetic ingredients.

Source

• Natural Sources: Found in meat, fish, eggs, green vegetables and grains

• Commercial Production: Synthesized from nicotinic acid through amidation process for pharmaceutical-grade purity

Main Functions

• Barrier Enhancement: Increases ceramide production for stronger skin barrier

• Sebum Regulation: Normalizes oil production without over-drying

• Anti-Pigmentation: Inhibits melanosome transfer to keratinocytes

• Anti-Inflammatory: Reduces cytokines involved in acne and rosacea

Skincare Benefits & Applications

• Barrier Repair & Hydration: Ideal for dry/sensitive skin formulations (2-5%)

• Acne Treatment: Reduces sebum production and inflammation (4-5%)

• Anti-Aging: Boosts collagen production and reduces fine lines (5%)

• Brightening: Fades dark spots and evens skin tone (3-5%)

• Pore Minimizing: Regulates sebum and improves skin texture (2-4%)

Medical & Dermatological Potential

• FDA-approved for treatment of acne vulgaris and inflammatory skin conditions

• Studied for skin cancer prevention (non-melanoma) through DNA repair

• Potential in treating rosacea and atopic dermatitis

• Emerging research in topical use for psoriasis management

Safety & Suitable Users

• Exceptionally safe with no known toxicity at cosmetic doses (up to 5%)

• Non-irritating and non-comedogenic

• Suitable for all skin types including sensitive, acne-prone and rosacea

• Can be used alongside other actives (retinoids, vitamin C, acids)

• No photosensitivity risk – safe for daytime use

📦 Support and Documentation

We provide complete technical support, including:

• TDS (Technical Data Sheet)

• COA (Certificate of Analysis)

• MSDS (Material Safety Data Sheet)

• Sample support and formulation guidance available upon request