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Hydrolyzed Sodium Hyaluronate

Ultra-Low Molecular Weight Enzymatic Technology for Superior Transdermal Absorption

While traditional Hyaluronic Acid sits on the skin surface to provide hydration, Hydrolyzed Sodium Hyaluronate is engineered for depth. Utilizing advanced enzymatic cleavage technology by Shaanxi Huatai Bio-fine Chemical Co., we have reduced the molecular weight to below 10,000 Daltons. This “ultra-mini” size allows the molecules to bypass the stratum corneum and penetrate deep into the dermis. It is not just a humectant; it is a bioactive signal that rehydrates the skin from within, repairs damaged cells, and significantly enhances the efficacy of co-formulated actives.

CAS No.	9067-32-7
Source	Microbial Fermentation with Specialized Enzymatic Cleavage
Appearance Color	White to Off-white Powder
Key Parameter	Molecular Weight < 10,000 Daltons / Purity >= 95.0%
Solubility	Highly Water-soluble

1. Key Specifications & Technical Parameters (Commercial Comparison)

Feature	Shaanxi Huatai Standard	Market Advantage
Molecular Weight	< 10,000 Da (Ultra-Low)	Deepest penetration compared to standard “Low MW” HA
Absorption Rate	High Transdermal Flux	Reaches the dermis within minutes of application
Processing Tech	Precision Enzymatic Cleavage	Maintains molecular integrity without chemical degradation
Bio-Activity	Cell-Signaling Properties	Acts as a signal to stimulate internal HA production
Purity (HPLC)	>= 95.0%	Minimal protein residue; extremely high skin tolerance
Skin Feel	Water-like / Non-sticky	Zero tackiness; feels like fresh water upon application

2. Biological Mechanism of Action (MoA)

Our Hydrolyzed Sodium Hyaluronate operates through three primary pathways:

Deep Dermal Hydration: Due to its ultra-small size, it travels through intercellular spaces to deliver moisture directly to the deeper epidermal and dermal layers, “plumping” the skin from the inside out.
Cellular Repair & Signaling: Acts as a biological signal to activate CD44 receptors on fibroblasts, triggering the synthesis of endogenous Hyaluronic Acid and Type I Collagen.
Scavenging Free Radicals: Effectively neutralizes internal ROS (Reactive Oxygen Species) induced by UV radiation, providing deep-tissue protection against photo-aging.

3. Formulation & Processing Guidelines

Parameter	Recommended Standard	Formulation Tip
Usage Level	0.1% to 1.0% (Standard)	High efficacy; often used as the “hero” active for hydration
Intensive Care	Up to 2.0%	Optimized for deep-repair ampoules and clinical-grade serums
Optimal pH Range	4.0 to 8.0	Extremely stable in both acidic and neutral environments
Processing Temp	Below 80°C	Excellent heat stability; can be added during most phases
Synergy Tip	Penetration Enhancer	Use it to help “carry” other larger actives into the skin

4. Market Advantages & Synergies

“Next-Gen” Hydration: Appeals to the sophisticated consumer who understands that “surface hydration” is not enough for long-term anti-aging.
Versatile Delivery: Its water-like consistency makes it perfect for “toner-essences,” light serums, and oil-in-water emulsions where a heavy texture is undesirable.
Medical-Aesthetic Support: An essential active for post-microneedling or post-laser care to provide instant deep-tissue rehydration.

Recommended Synergistic Blends:

Hydrolyzed HA + Sodium DNA: For a comprehensive “Inside-Out” repair system (Dermal hydration + DNA repair).
Hydrolyzed HA + Retinal: Deeply hydrates the skin to offset the dryness often caused by Vitamin A derivatives.
Hydrolyzed HA + High MW HA: The “Full-Spectrum” approach—High MW for surface locking and Ultra-Low MW for deep filling.

5. Quality Assurance & Regulatory Support

Certifications: Manufactured in an ISO 9001 and ISO 22000 certified facility.
Technical Dossier: We provide complete TDS, MSDS, and COA to support global regulatory compliance and transdermal claims.
Applications: Ideal for “Deep-Drip” essences, anti-aging ampoules, hydrating toners, and regenerative sheet masks.

6. Partner with Shaanxi Huatai Bio-fine Chemical Co.

Request a Technical Dossier: Access full transdermal penetration studies and MW analysis.
Apply for a Free Sample: Experience the rapid absorption of our <10k Dalton Hydrolyzed HA.
Customized Quote: Discuss bulk pricing and tailored molecular weight ranges.

Why choose us

Premium Bulk Active Ingredients Manufacturer & Wholesale Suppliers

Shaanxi Huatai Bio-Fine Chemicals Co., Ltd. is a specialized manufacturer of advanced Functional Skincare Ingredients, providing scalable wholesale solutions for global beauty brands. We offer high-purity bulk supplies of Glabridin (brightening), Licochalcone A (anti-acne), Totarol, and Dipotassium Glycyrrhizinate. With tailored concentrations (1%–99%) and comprehensive OEM capabilities, our ISO 9001/22000 and COSMOS certified facilities guarantee premium cosmetic-grade quality for every wholesale order.

Hydrolyzed Sodium Hyaluronate