Liquiritigenin
Targeted Relief for Neurogenic Stinging and Instant Redness Reduction
Liquiritigenin is a high-potency flavonoid aglycone isolated from the root of the licorice plant. Unlike traditional soothing agents that take hours to show results, Liquiritigenin is engineered by Shaanxi Huatai Bio-fine Chemical Co. to provide “flash-acting” relief. It specifically targets the TRP (Transient Receptor Potential) channels in the skin to switch off neurogenic stinging and burning sensations. Its ultra-small molecular weight allows for rapid penetration, making it the premier choice for professional-grade “anti-redness” formulas and immediate-response soothing products.
| CAS No. | 578-86-9 |
|---|---|
| Source | High-Purity Licorice Root (Glycyrrhiza glabra) Extract |
| Appearance Color | White to Off-white Crystalline Powder |
| Key Parameter | Purity >= 98.0% (HPLC) |
| Solubility | Soluble in Ethanol, Propylene Glycol, and DMSO; sparingly soluble in water |
1. Key Specifications & Technical Parameters (Commercial Comparison)
| Feature | Shaanxi Huatai Standard | Market Advantage |
| Soothing Speed | Instant “Flash” Relief | Significantly faster than traditional glycyrrhizinates |
| Target Mechanism | Neuro-sensory Blockade | Directly targets stinging and burning at the nerve level |
| Purity (HPLC) | >= 98.0% (Premium Grade) | Crystalline purity ensures high efficacy and low impurity risk |
| Brightening Potency | Dual-Action Benefit | Provides substantial skin brightening alongside soothing |
| Skin Penetration | Low Molecular Weight | Superior transdermal delivery compared to larger molecules |
| Stability Profile | Excellent pH Stability | Remains active across a wide range of cosmetic pH values |
2. Biological Mechanism of Action (MoA)
Our Liquiritigenin operates through three primary pathways:
Neurogenic Inhibition: Effectively modulates sensory nerve activation, specifically targeting the receptors responsible for “burning” and “stinging” sensations in sensitive or compromised skin.
Rapid Erythema Reduction: Inhibits the production of prostaglandin E2 (PGE2) and inflammatory cytokines, leading to the rapid visible reduction of skin redness (erythema).
Tyrosinase Modulation: Offers secondary brightening benefits by regulating the melanin production pathway, making it ideal for treating post-inflammatory hyperpigmentation (PIH).
3. Formulation & Processing Guidelines
| Parameter | Recommended Standard | Formulation Tip |
| Usage Level | 0.05% to 0.3% (Standard) | High efficacy at extremely low concentrations |
| Intensive Care | Up to 0.5% | For professional “SOS” ampoules or post-laser relief |
| Optimal pH Range | 4.0 to 7.5 | Stable in the most common professional environments |
| Processing Temp | Below 60°C | Add during the cooling phase to preserve crystal integrity |
| Solubility Note | Glycol-based | Pre-dissolve in polyols (Propanediol/Butylene Glycol) for uniform dispersion |
4. Market Advantages & Synergies
The “Sensory” Specialist: Perfect for brands marketing to consumers with “hyper-reactive” skin who demand immediate comfort.
Post-Procedure Recovery: An essential active for soothing skin after chemical peels or intensive heat-based aesthetic treatments.
Clean Beauty Hero: A natural, plant-derived molecule that offers pharmaceutical-level performance without synthetic steroids.
Recommended Synergistic Blends:
Liquiritigenin + Sodium DNA: Combines rapid neuro-soothing with deep-core DNA-level tissue repair.
Liquiritigenin + Hydroxytyrosol: Creates a powerful shield against both oxidative stress and inflammatory redness.
Liquiritigenin + Allantoin: The ultimate “Healing & Soothing” duo to repair the barrier while stopping the sting.
5. Quality Assurance & Regulatory Support
Certifications: Manufactured in an ISO 9001 and ISO 22000 certified facility.
Technical Dossier: We provide complete TDS, MSDS, and COA to support global regulatory compliance and dermatological claims.
Applications: Ideal for immediate-relief serums, anti-redness masks, post-procedure recovery gels, and sensitive skin toners.
6. Partner with Shaanxi Huatai Bio-fine Chemical Co.
Request a Technical Dossier: Access full safety, stability, and anti-stinging efficacy reports.
Apply for a Free Sample: Experience the rapid calming effect of our 98% purity Liquiritigenin.
Customized Quote: Discuss bulk pricing and tailored polyol-dispersion solutions.
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