Biotin
Biotin (Hydroxypropyl Tetrahydropyrantriol) is a C-glycoside anti-aging active ingredient derived from beech xylose. Its core strength lies in its ability to promote the synthesis of Glycosaminoglycans (GAG) and dermal-epidermal junction (DEJ) components, leading to an increase in epidermal tissue thickness, improved firmness, and significant wrinkle reduction, making it a foundation for premium anti-aging formulations.
| INCI Name | Hydroxypropyl Tetrahydropyrantriol |
|---|---|
| CAS No. | 439685-79-7 |
| Source | A xylose derivative discovered from mountain birch tree |
| Purity | ≥98% (Powder) or ≥30% (Liquid Solution) |
| Core Function | Anti-aging effects, wrinkle resistance, promote $\text{GAG}$ synthesis, enhance $\text{DEJ}$ structure, skin hydration. |
1. Product Overview & Market Relevance
Hydroxypropyl Tetrahydropyrantriol is a recognized and widely adopted ingredient in high-performance cosmetic production, particularly known under the trade name Pro–Xylane. It is a group of raw materials composed of water, propylene glycol, and the core C-glycoside component. This ingredient is highly valued for its efficacy in improving skin structure, being easily biodegradable, and non-toxic.
2. Technical Highlights and Critical Parameters
2.1 Mechanism of Action
GAG Production: Hydroxypropyl Tetrahydropyrantriol promotes the generation of endogenous Glycosaminoglycans (GAG), such as hyaluronic acid, increasing the water content and density of the extracellular matrix.
DEJ Repair/Collagen Support: Promotes the synthesis of type IV and type VII collagen and laminin-5, improving the ultrastructure of the dermal-epidermal junction (DEJ) for a tighter connection between the epidermis and dermis.
2.2 Standard Technical Specifications (Combined Data)
| Parameter | Powder Standard (≥98%) | Liquid Solution Standard (≥30%) |
| Appearance | White Powder | Colorless to pale yellow viscous liquid |
| Purity/Content | ≥ 98% | ≥ 30% (Active Content) |
| Solubility | Soluble in water | Miscible with water |
| Recommended $text{pH}$ | 3.8–7.0 (Must be within this range in the final formula) | 3.8–7.0 |
| Usage Rate | 0.5%–10% (Recommended 2%–5% in the final formula) | 0.5%–10% (Recommended 2%–5% in the final formula) |
3. Market Positioning and Core Advantages
Targeted Dermal Repair: Directly addresses the loss of dermal structural integrity and water retention by boosting GAG and DEJ$ synthesis.
Proven Clinical Efficacy: Clinical studies demonstrate improvement in fine lines around the eyes and neck folds within 60 days of use.
Increased Epidermal Thickness: Scientific models show an increase in epidermal tissue thickness after 8 days of cultivation, indicating potential for barrier strengthening and plumping.
Global Recognition: Used widely by major global skincare brands, establishing it as a premium, highly effective anti-aging benchmark.
4. Formulation Guidelines
Integration Phase: Due to its water solubility, the liquid form should be mixed into the aqueous phase. The powder form requires dissolution prior to final integration. It can withstand heat up to 80°.
Concentration: The typical cosmetic usage rate is between 2%–5% of the finished formula.
pH Control: The final formulation pH must be maintained within the range of 3.8–7.0 for optimal stability and efficacy.
5. Quality Assurance and Regulatory Confidence
Our quality and safety credentials include:
COSMOS (Natural and Organic Cosmetic Standard)
ISO 9001 Quality Management System
ISO 22000 Food Safety Management System
HALAL Certification
IQNET (The International Certification Network)
Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)
6. Typical Applications
Premium Anti-Aging: Serums, creams, and lotions marketed for wrinkle reduction, skin firmness, and elasticity.
Targeted Care: Eye creams and neck creams, given the proven efficacy against fine lines in these areas.
Hydration/Barrier Repair: Moisturizers where enhanced $text{GAG}$ production provides long-term hydration and improved barrier strength.
7. Scientific Evidence Summary
Collagen Production: Hydroxypropyl Tetrahydropyrantriol accelerates the production of type IV and type VII collagen by dermal cells, significantly enhancing the dermal epidermal network connection.
Dermis Repair: By promoting GAG synthesis, it indirectly increases collagen production, achieving the effects of dermis repair, improved skin elasticity, and increased skin firmness.
Clinical Results: Clinical trials demonstrate significant improvement in neck fine lines after 60 days, making the skin appear fuller, tighter, and more elastic.
8.Frequently Asked Questions
Q1: How does Hydroxypropyl Tetrahydropyrantriol impact the dermal structure?
A: It actively promotes the synthesis of GAG (like Hyaluronic Acid) and DEJ components (Collagen VII, Laminin-5), strengthening the dermal-epidermal bond and providing structural support for improved firmness.
Q2: What is the typical inclusion rate for best results?
A: While usage rates range from 0.5%-10%, a highly recommended concentration in the finished formula for optimal anti-aging results is 2%-5%.
Q3: Is this ingredient suitable for sensitive formulations?
A: Yes. Hydroxypropyl Tetrahydropyrantriol is easily biodegradable, non-toxic, and known for its high purity, making it a reliable choice for premium cosmetic use.
Source our High-Purity Hydroxypropyl Tetrahydropyrantriol (Bosonine) to formulate advanced anti-aging products that actively promote GAG synthesis and dermal-epidermal junction repair.
🔒 Get Your Technical Dossier: Access TDS, MSDS, COA, and Clinical Efficacy Reports.
🔬 Apply for a Free Sample: Test the stable, high-efficacy immune-boosting power of Hydroxypropyl Tetrahydropyrantriol today.
📞 Get a Customized Quote: Discuss bulk orders and high-purity specifications.
English
German
Spanish
French
Japanese
Korean
Portuguese