Gamma-Polyglutamic Acid

Gamma-Polyglutamic Acid is a natural, anionic biopolymer produced through the fermentation of Bacillus subtilis. It is celebrated as a super-humectant, capable of binding significantly more water than Hyaluronic Acid. Gamma-Polyglutamic Acid not only provides intensive, deep hydration but also uniquely enhances skin elasticity, inhibits the enzyme responsible for Hyaluronic Acid degradation, and improves the overall Skin Natural Moisturizing Factor (NMF) composition.

INCI Name

Polyglutamic Acid

CAS No.

25513-46-6

Source

Biotechnological Fermentation

Appearance

White to off-white powder or viscous solution

Core Function

Super-Humectant, Elasticity Enhancement, HA Degradation Inhibition, NMF Boost, Barrier Support

The New Standard in Moisture: Gamma-Polyglutamic Acid (γ-PGA) for Superior Bio-Hydration

For high-end beauty brands, the limitations of traditional humectants are clear: surface-level hydration is insufficient, and moisture evaporation remains a constant threat to formulation efficacy. As consumer demand shifts toward clinical-grade, biotechnologically advanced ingredients, Gamma-Polyglutamic Acid (γ-PGA) has emerged as the definitive successor to standard Hyaluronic Acid. By combining a massive water-binding capacity with the rare ability to preserve the skin’s endogenous moisture, this natural fermentation-derived active empowers formulators to create the next generation of plumping, barrier-reinforcing, and age-defying skincare.

Unrivaled Efficacy: Clinical & Laboratory Proof

  • 5,000x Water Binding: Possesses an extraordinary capacity to bind up to 5,000 times its weight in water, creating a powerful, long-lasting moisture reservoir that outperforms standard Hyaluronic Acid in comparative clinical studies.

  • Hyaluronidase Inhibition: Acts as a potent inhibitor of Hyaluronidase, the enzyme responsible for the degradation of endogenous Hyaluronic Acid, effectively protecting the skin’s native moisture-retention pathways.

  • Biotech-Driven NMF Synthesis: Actively stimulates the production of Natural Moisturizing Factors (NMFs) such as UCA and Lactic Acid, providing a sustainable, deep-tissue hydration boost.

  • Immediate Plumping Effect: Creates a breathable, non-tacky film that minimizes Transepidermal Water Loss (TEWL) while providing a rapid smoothing and firming effect on the skin’s surface.

Core Specifications & Technical Parameters

ParameterSpecification
Molecular Weight>100 kDa (High MW for film-forming)
Active PurityStandardized concentration (Aqueous solution/Powder)
AppearanceClear to slightly opalescent liquid / White powder
SolubilityHighly water-soluble
pH Stability Range4.0 – 7.0
Recommended Dosage0.05% – 0.5% (as high-purity powder)
Shelf Life24 Months
StorageStore in a cool, dark, sealed container

Formulation Intelligence: The “Golden Synergy” Blends

Accelerate your R&D pipeline with these strategically optimized pairings:

  • The “Total Moisture” Matrix: Combine with Glycerin and low-molecular weight Hyaluronic Acid. While the Glycerin draws immediate water into the stratum corneum, the γ-PGA “locks” it in and prevents degradation, providing a multi-layer, 24-hour hydration architecture.

  • The “Luminous Barrier” Complex: Pair with Niacinamide. This synergy repairs the skin barrier while providing an immediate smoothing effect, perfect for high-performance serums that target both texture and dullness.

  • The “Structural Age-Defiance” Serum: Integrate with Vitamin C Derivatives. The γ-PGA provides the stable hydration necessary to mitigate the potential irritation of active Vitamin C while the plumping effect of the PGA maximizes the anti-aging visual results.

Quality Assurance & Regulatory Excellence

Our production facility operates at the intersection of biotechnology and compliance, providing the documentation required for the most stringent global markets:

  • ISO 9001

  • ISO 22000

  • COSMOS

  • HALAL

  • IQNET

Our comprehensive technical dossier—including TDS, MSDS, COA, and clinical comparative hydration studies—is available to support your regulatory and safety assessment teams.

Secure Your Competitive Edge in Moisture Tech

Standard hydration is a commodity; clinical-grade moisture is a competitive advantage. Move your formulations beyond the limitations of legacy humectants and integrate the superior performance of Gamma-Polyglutamic Acid.

Contact our technical advisory team to secure your professional evaluation samples and gain immediate, priority access to our full library of technical validation reports and stability studies.

Request your technical dossier and premium-grade samples today to initiate the next generation of high-potency, super-hydrating skincare.

Shaanxi Huatai Bio-Fine Chemicals Co., Ltd. is a specialized manufacturer of advanced Functional Skincare Ingredients, providing scalable wholesale solutions for global beauty brands. We offer high-purity bulk supplies of Glabridin (brightening), Licochalcone A (anti-acne), Totarol, and Dipotassium Glycyrrhizinate. With tailored concentrations (1%–99%) and comprehensive OEM capabilities, our ISO 9001/22000 and COSMOS certified facilities guarantee premium cosmetic-grade quality for every wholesale order.

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