Gamma-Polyglutamic Acid is a natural, anionic biopolymer produced through the fermentation of Bacillus subtilis. It is celebrated as a super-humectant, capable of binding significantly more water than Hyaluronic Acid. Gamma-Polyglutamic Acid not only provides intensive, deep hydration but also uniquely enhances skin elasticity, inhibits the enzyme responsible for Hyaluronic Acid degradation, and improves the overall Skin Natural Moisturizing Factor (NMF) composition.
| INCI Name | Polyglutamic Acid |
|---|---|
| CAS No. | 25513-46-6 |
| Source | Biotechnological Fermentation |
| Appearance | White to off-white powder or viscous solution |
| Core Function | Super-Humectant, Elasticity Enhancement, HA Degradation Inhibition, NMF Boost, Barrier Support |
For high-end beauty brands, the limitations of traditional humectants are clear: surface-level hydration is insufficient, and moisture evaporation remains a constant threat to formulation efficacy. As consumer demand shifts toward clinical-grade, biotechnologically advanced ingredients, Gamma-Polyglutamic Acid (γ-PGA) has emerged as the definitive successor to standard Hyaluronic Acid. By combining a massive water-binding capacity with the rare ability to preserve the skin’s endogenous moisture, this natural fermentation-derived active empowers formulators to create the next generation of plumping, barrier-reinforcing, and age-defying skincare.
5,000x Water Binding: Possesses an extraordinary capacity to bind up to 5,000 times its weight in water, creating a powerful, long-lasting moisture reservoir that outperforms standard Hyaluronic Acid in comparative clinical studies.
Hyaluronidase Inhibition: Acts as a potent inhibitor of Hyaluronidase, the enzyme responsible for the degradation of endogenous Hyaluronic Acid, effectively protecting the skin’s native moisture-retention pathways.
Biotech-Driven NMF Synthesis: Actively stimulates the production of Natural Moisturizing Factors (NMFs) such as UCA and Lactic Acid, providing a sustainable, deep-tissue hydration boost.
Immediate Plumping Effect: Creates a breathable, non-tacky film that minimizes Transepidermal Water Loss (TEWL) while providing a rapid smoothing and firming effect on the skin’s surface.
| Parameter | Specification |
| Molecular Weight | >100 kDa (High MW for film-forming) |
| Active Purity | Standardized concentration (Aqueous solution/Powder) |
| Appearance | Clear to slightly opalescent liquid / White powder |
| Solubility | Highly water-soluble |
| pH Stability Range | 4.0 – 7.0 |
| Recommended Dosage | 0.05% – 0.5% (as high-purity powder) |
| Shelf Life | 24 Months |
| Storage | Store in a cool, dark, sealed container |
Accelerate your R&D pipeline with these strategically optimized pairings:
The “Total Moisture” Matrix: Combine with Glycerin and low-molecular weight Hyaluronic Acid. While the Glycerin draws immediate water into the stratum corneum, the γ-PGA “locks” it in and prevents degradation, providing a multi-layer, 24-hour hydration architecture.
The “Luminous Barrier” Complex: Pair with Niacinamide. This synergy repairs the skin barrier while providing an immediate smoothing effect, perfect for high-performance serums that target both texture and dullness.
The “Structural Age-Defiance” Serum: Integrate with Vitamin C Derivatives. The γ-PGA provides the stable hydration necessary to mitigate the potential irritation of active Vitamin C while the plumping effect of the PGA maximizes the anti-aging visual results.
Our production facility operates at the intersection of biotechnology and compliance, providing the documentation required for the most stringent global markets:
ISO 9001
ISO 22000
COSMOS
HALAL
IQNET
Our comprehensive technical dossier—including TDS, MSDS, COA, and clinical comparative hydration studies—is available to support your regulatory and safety assessment teams.
Standard hydration is a commodity; clinical-grade moisture is a competitive advantage. Move your formulations beyond the limitations of legacy humectants and integrate the superior performance of Gamma-Polyglutamic Acid.
Contact our technical advisory team to secure your professional evaluation samples and gain immediate, priority access to our full library of technical validation reports and stability studies.
Request your technical dossier and premium-grade samples today to initiate the next generation of high-potency, super-hydrating skincare.
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